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President's Remarks | Journal
Highlights | Lifetime Achievement Award
| Fund for the Future Contributors |
Distinguished Service Awards |
2004 SIVB Student Awards | Meeting Updates
| ExPlants |
Points to Ponder | News from the IAPTC&B
| Statement of Ownership
The Distinguished Service Award is presented to those, selected
by the SIVB President, who have demonstrated and given extra effort
in support of the SIVB programs and endeavors. The following SIVB
members were presented the Distinguished Service Award at the
2004 World Congress, held in San Francisco, California. Additional
winners will be listed in future issues of the In Vitro Report.
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 Barbara
Doonan
In September 2004, Barbara Doonan celebrated 25 years as a
scientist in industry. Her current position is Lead Senior
Scientist at UST Inc. in Greenwich CT. At UST since 1989,
she has enjoyed the opportunity to apply her broad background
and expertise in biochemistry, molecular biology and toxicology
to address company interests in areas such as plant biotechnology
and health issues. Just prior to joining UST, Dr. Doonan was
a visiting scientist at the Cold Spring Harbor laboratory
of Dr. Elizabeth Moran researching cell cycle control in the
adenovirus E1A system utilizing recombinant technologies.
Her career in industry was initiated in 1979 at General Foods
Corporation (GF) as a Research Scientist in the Nutrition
and Health division directing such as short term animal toxicology
GLP studies and studies designed to determine carcinogenic
and mutagenic potential of various compounds e.g. halogenated
hydrocarbons. Many of these projects were conducted in support
of GF's domestic and international coffee businesses addressing
questions as to its safety aspects. This provided an excellent
in depth introduction to this crop for Dr. Doonan which was
enhanced further as she transitioned into GF's Biotechnology
Programs group to assume the direction of studies utilizing
cell culture and microbial fermentation technologies for production
of natural compounds e.g. specific flavors/unique enzymes
from coffee precursors. In addition to teaching duties while
a graduate student, research at the Master's level focused
on the study of bacteria and their viruses via development
of a novel transformation system. Building on this foundation,
she further expanded her background concentrating on the biosynthesis
and metabolism of phosphate compounds in cyanobacteria and
the development of improved techniques for visualization of
enzyme activities at the molecular level. After receiving
her doctoral degree from City University of New York, Dr.
Doonan spent a year as an assistant professor at William Paterson
College in Wayne NJ teaching general biology, human anatomy
and physiology and electron microscopy. She is a member of
Phi Beta Kappa, Sigma Xi, the Society of In Vitro Biology
and a number of other professional societies.
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Gertrude C. Buehring
My professional career began at the University of California
at Berkeley 31 years ago when I was hired on the faculty of
the Infectious Division of the School of Public Health. I
have been there ever since. I teach two undergraduate courses,
Public Health Microbiology, lecture and laboratory component.
I teach one graduate course called "Viruses and Human
Cancer" and occasionally offer special seminar courses.
Throughout my time on the faculty here, I have maintained
a research program on human breast cancer and have mentored
in my laboratory over 20 Ph.D. students. Initially I worked
on developing methods to grow human mammary epithelial cells
in culture and study their characteristics, e.g. morphology,
antigen expression, hormone responsiveness. For the past 15
years I have focused on exploring the possibility that bovine
leukemia virus (BLV) might play a causal role in the development
of human breast cancer. Our laboratory has been funded for
this research for the past 8 years and has been able to unravel
some important information about the basic biology of BLV,
as well as to study its ability to infect humans and its association
with breast cancer. Cell culture has been a methodology important
in my research and I have valued my membership in SIVB (since
1978) and attendance at meetings as an important way to keep
up with advances in the field. I have particularly enjoyed
the friendships and collegial relationships I have developed
with other scientists in SIVB.
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Glyn Stacey
Glyn Stacey's early scientific background was been in microbiology
and cancer research. He has established special interests and
activities in the field of cell biology relating to genetic
stability, safety issues and standardization. This has also
lead to involvement in a range of related areas including plant
tissue culture, cell preservation and management of biological
resources. From 1989-1998 he worked at the Centre for Applied
Biology and Research where he was involved in developing cell
culture and cell banking procedures and in establishing a cell
biology unit working on the development of cell substrates for
manufacture of medical products and cell-based diagnostic assays.
Part of Dr Stacey's initial work at NIBSC was focused on creating
a new suite of clean-room laboratories designed to operate under
GMP accreditation for cell banking. At NIBSC he has developed
a broad remit on the development appropriate cell biology activities
relevant to the quality and safety of new biological medicines
and therapies based on the use of human and animal cells. In
addition to developing a research portfolio in this area, he
has also acted as an advisor to the UK Department of Health
and the World Health Organization and was a member of the consultation
group that drafted the UK Code of Practice for the Production
of Human-derived Therapeutic Products (June 2002). He has organized
the NIBSC Stem Cell Liaison Group which provides an open forum
for discussion amongst a variety of health care workers on safety
and quality issues in the preparation of harvested haematopoietic
stem cells for transplantation. He is now in charge of the UK
Stem Cell Bank funded by the Medical Research Council and BBSRC
to prepare banks of stem cell lines for use in research and
in the development of new therapies and in addition is a visiting
Professor on a new international postgraduate course in Cryobiology
at the University of Luton. |
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 Craig
Meyers
The major interest of our laboratory is to understand
the differentiation-dependent replication of papillomaviruses
and their role in carcinogenesis. Human papillomaviruses (HPV)
are important human pathogens associated with benign and malignant
neoplasias. HPV is the major risk factor in the development
of cervical cancer. A major obstacle was once the inability
to study the HPV life cycle in vitro. Using an organotypic
(raft) culture system, my laboratory demonstrated for the
first time the complete HPV life cycle in vitro, concomitant
with the induction of a more complete differentiation program
of the host tissue. The organotypic raft culture system faithfully
mimics three-dimensional epithelial physiology in an in
vitro model system. Using this in vitro organotypic
culture system we are analyzing the steps and mechanisms (viral
and cellular) involved in viral DNA replication, gene expression,
and oncogenesis. We are identifying and investigating the
role of cofactors, such as other viruses and hormones, in
the carcinogenic process. We have also developed numerous
genetic systems to study the natural history of HPV infection
in vitro. Additionally, we are using our system to support
vaccine and therapeutic drug studies.
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